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Center for Integrated Bioinformatics
School of Biomedical Engineering, Science & Health Systems, Drexel University
31st & Market Street, Bossone Research Center, Philadelphia, PA 19104
Phone (215) 895-2791 Details.



School of Biomedical Engineering
Aydin Tozeren, Ph.D. Distinguished Professor and Director
School Of Biomedical Engineering, Science & Health Systems, Drexel University
Office:  Bossone Building # 704  Email: at62@drexel.edu
Phone: (215) 895-6148  Fax: (215) 895-4983


Biosketch

Dr. Aydin Tozeren received his Ph.D. from Columbia University in 1974. Since then, he has published in the areas of cell adhesion and signaling , molecular basis of muscle contraction, biomechanics, and mathematical modeling of biological systems. Dr. Tozeren's book Human Body Dynamics: Classical Mechanics and Human Movement received the Best Engineering Title Award for the year 2000 by the Association of American Publishers. His new book, New Biology for Engineers and Computer Scientists introduces the basic elements of system biology to engineers, physicists and computer scientists. Dr. Tozeren held academic and research positions at Columbia University, the National Institutes of Health, and the Catholic University of America, where he served as the chair of the Department of Biomedical Engineering. Dr. Tozeren received and directed research grants from the National Science Foundation, the National Institutes of Health, the Department of Defense Breast Cancer Research Fund, as well as a recent biomedical engineering infrastructure special opportunity grant from the Whitaker Foundation. Dr. Tozeren has taught a large number of graduate and undergraduate courses, guided doctoral dissertations, and in 1996, received the Alpha Delta Gamma Outstanding Teacher Award at the Catholic University of America. During the year 2001, he served as a member of the Board of Scientific Advisors of the Whitaker Foundation. Currently he is a professor of Biomedical Engineering at Drexel University and the Director of Drexel's Integrated Bioinformatics Program.


Research Keywords

Breast cell adhesion and communication, signal transduction networks in cancer and epithelial cells, integrated bioinformatics, molecular profiling.


Active Research Projects

Origin and evolution of cell phenotypes in growing breast tumors
Bioinformatics of chromosome aberrations in breast cancer
Automated histology of breast cancer


Education &

Ph.D., Columbia University, Bioengineering concentration, 1974
M.S., Columbia University, Engineering mechanics, 1972
B.S., Orta Dogu Technical University, Ankara, TR, 1971


Selected Publications @
  1. Ertel A, Tozeren A (2008) Switch-like genes populate cell communication pathways and are enriched for extracellular proteins. BMC Genomics, 9: 3. (pdf)
  2. Gormley M, Dampier W, Ertel A, Karacali B, Tozeren A (2007). Prediction potential of candidate biomarker sets identified and validated on gene expression data from multiple datasets. BMC Bioinformatics 8: 415 (pdf)
  3. Dampier W., Tozeren A. (2007) Signaling Perturbations Induced by Invading H. pylori Proteins in the Host Epithelial Cells: A Mathematical Modeling Approach. Journal of Theoretical Biology 248:130-44. (pdf)
  4. Ertel A, Verghese A, Byers S, Ochs M, Tozeren A (2006) Pathway Specific Differences Between Tumor Cell Lines and Normal and Tumor Tissue Cells, BMC-Molecular Cancer 5: 55 (pdf)
  5. Tozeren A, Coward C, Petushi S (2005) Origins and Evolution of Cell Phenotypes in Breast Tumors. Journal of Theoretical Biology: 233/1: 43-54. (pdf)
  6. Petushi, S, Garcia, FU, Haber, MM, Katsinis, C, Tozeren A (2006) Large Scale Computations on Histology Images Reveal Grade-Differentiating Parameters for Breast Cancer, BMC-Medical Imaging 6: 14. (pdf)
  7. Vamvakidou, A, Mondrinos, MS, Petushi, SP, Garcia, FU, Lelkes, PI, Tozeren, A (2006) Heterogeneous Breast Tumoroids: An In Vitro Assay for Investigating Cellular Heterogeneity and Drug Delivery, Journal of Biomolecular Screening 12(1):13-20. (pdf)
  8. Karacali, B.; Tozeren A (2007), "Automated Detection of Regions of Interest for Tissue Microarrays: An Image Texture Analysis," BMC Medical Imaging Mar 9;7:2. (pdf)
  9. Avvisato CL, Yang X, Shah S, Hoxter B, Li W, Gaynor R, Pestell R, Tozeren A, Byers SW. (2007) Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. J Cell Science.: 2672-82. (pdf)
  10. Karacali B, Vamvakidou A, Tozeren A (2007). Automated recognition of cell phenotypes in histology images based on membrane- and nuclei-bound biomarkers. BMC Medical Imaging 7:7 (pdf)
  11. Tozeren A., Byers S.W., New Biology for Engineers and Computer Scientists, NJ: Prentice Hall (2003).
  12. Tozeren A., Sung K.L.P., Sung L.A., Dustin M.L., Chan P-Y., Springer T.A., and Chien S., Micromanipulation of Adhesion of a Jurkat Cell to a Planar Membrane Containing either Mobile or Immobile LFA-3 Molecules, J. Cell Biol., 116:997-1006 (1992).
  13. Tozeren A., Cell-Cell Conjugation: Transient Analysis and Experimental Implications, Biophys. J., 58:641-652, (1990).
  14. Tozeren A., Mackie L.H., Lawrence M.B., Chan P-Y., Dustin M.L., and Springer T.A., The Interaction of PMA-stimulated T Lymphocytes with Planar Membranes Containing Intercellular Adhesion Molecules, Biophys. J., 63:247-258 (1992).
  15. Tozeren A., and Ley K., How Do Selectins Mediate Leukocyte Rolling in Blood Vessels?, Biophys. J., 63:700-709 (1992).
  16. Tozeren A., Kleinman H.K., Wu S., Mercurio A.M., and Byers S.W., Integrin 64 MediatesDynamic Interactions with Laminin, J. Cell Science, 107:3153-3163 (1994).
  17. Tozeren A., Kleinman H.K., Grant D.S., Morales D., Mercurio A.M., and Byers S.W., E-Selectin-Mediated Dynamic Interactions of Breast and Colon Cells With Endothelial-Cell Monolayers, Int. J. Cancer, 60:426431 (1995).
  18. Byers S.W., Sommers C.L., Hoxter B., Mercurio A.M., and Tozeren A., The Role of E-Cadherin in the Response of Tumor Cell Aggregates to Lymphatic, Venous and Arterial Flow: Measurement of Cell-Cell Adhesion Strength, J. Cell Sci., 108:2053-2064, (1995).
  19. Brooks S., and Tozeren A., Laminar Flow Past an Array of Cells that are Adherent to Bottom Plate of a Flow Channel, Computations and Fluids, 25:741-757 (1996).
  20. Wu S., Hoxter B., Byers S.W., and Tozeren A., Role of Cytoskeleton ansd Deformability in Laminin-Mediated Rolling, Biorheology 35:37-51 (1998).

Awards

  • Alpha Delta Gamma Outstanding Instructor Award in 1996
  • Best Engineering Title for 2000 Award for Human Body Dynamic by the Association of American Publishers
  • Member, Academic Council, AIMBE
  • Guest Member, Board of Scientific Advisors, Whitaker Foundation
  • Director, Whitaker Foundation Special Opportunity Grant, 1999-2002
  • Grants from NSF and NIH

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